Substrate

Substrate is an AI revenue cycle platform for health systems and physician groups. Its agents handle denials, appeals, claim status, payment posting, credit balances, eligibility checks, and collections across more than 3,500 payers, working through EDI, direct APIs, and payer portals. Results are written back to practice management and EHR systems, with the company reporting first results within 48 hours and no engineering or IT integration project required.

The platform includes modules for Claim Status, Appeals/RFI, Posting, Credit Balance, Eligibility, Collections, and Payer Policy. The Claim Status agent combines EDI 276/277, clearinghouse data, browser-based portal agents, and direct APIs into a unified response, resolving payer name variations and routing automatically, then pushing statuses and next actions into billing worklists. It supports commercial, government, and portal-only payers, with an audit trail of screenshots and video for each agent action. Substrate states SOC 2 Type II and HIPAA compliance.

Substrate is packaged for health systems, hospitals, large physician groups, and scaled outsourced billers. A pay-as-you-go plan is available with usage-based pricing that scales down with volume, alongside an Enterprise edition priced to committed volume with SLAs, custom data exports, SSO/SAML, and custom reporting. A trial is offered on five claims with no contract or setup fee.